2-[5-(3-Chlorophenyl)-2-furanyl]-4,5-bis(4-methoxyphenyl)-1H-imidazole
- Product Name
- 2-[5-(3-Chlorophenyl)-2-furanyl]-4,5-bis(4-methoxyphenyl)-1H-imidazole
- CAS No.
- 937807-66-4
- Chemical Name
- 2-[5-(3-Chlorophenyl)-2-furanyl]-4,5-bis(4-methoxyphenyl)-1H-imidazole
- Synonyms
- Neurodazine;2-[5-(3-Chlorophenyl)-2-furanyl]-4,5-bis(4-methoxyphenyl)-1H-imidazole;1H-Imidazole, 2-[5-(3-chlorophenyl)-2-furanyl]-4,5-bis(4-methoxyphenyl)-;2-[5-(3-Chloro-phenyl)-furan-2-yl]-4,5-bis-(4-methoxy-phenyl)-1H-imidazole
- CBNumber
- CB32518979
- Molecular Formula
- C27H21ClN2O3
- Formula Weight
- 456.92
- MOL File
- 937807-66-4.mol
2-[5-(3-Chlorophenyl)-2-furanyl]-4,5-bis(4-methoxyphenyl)-1H-imidazole Property
- Boiling point:
- 661.4±55.0 °C(Predicted)
- Density
- 1.252±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: >20mg/mL
- form
- powder, yellow
- pka
- 12.84±0.10(Predicted)
- color
- Beige
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H318Causes serious eye damage
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- N6664
- Product name
- Neurodazine
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $189
- Updated
- 2024/03/01
- Product number
- N6664
- Product name
- Neurodazine
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $579
- Updated
- 2024/03/01
- Product number
- 13224
- Product name
- Neurodazine
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 13224
- Product name
- Neurodazine
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $153
- Updated
- 2024/03/01
- Product number
- 13224
- Product name
- Neurodazine
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $341
- Updated
- 2024/03/01
2-[5-(3-Chlorophenyl)-2-furanyl]-4,5-bis(4-methoxyphenyl)-1H-imidazole Chemical Properties,Usage,Production
Description
Neurodazine (937807-66-4) was able to induce neurogenesis of non-pluripotent myoblasts and cells derived from mature, human skeletal muscle (using 2 μM neurodazine). It was able to upregulate genes involved in neurogenesis (particularly B-cell translocation gene 2) without affecting those involved in myogenesis.
Uses
Neurodazine induces neurogenesis in mature skeletal muscle cells, via non-pluripotent C2C12 myoblasts.
Definition
ChEBI: 2-[5-(3-chlorophenyl)-2-furanyl]-4,5-bis(4-methoxyphenyl)-1H-imidazole is a member of imidazoles.
General Description
A cell-permeable trisubstituted imidazole compound that induces neurogenesis of non-pluripotent C2C12 myoblasts as well as cells derived from mature human skeletal muscle cultures (2 μM for 7-10 days). Shown to preferentially upregulate genes involved in neurogenesis, but not those pertaining to myogenesis, in C2C12 myoblasts.
Biochem/physiol Actions
Neurodazine is a promoter of neurogenesis. It induces a generation of new nerve cells from skeletal muscle fibers both immature, differentiated myotubes and mature skeletal muscle. Neurodazine promotes the expression of neuron-specific markers in treated C2C12 cells (neurogenesis). In addition, in conjunction with a microtubule-destabilizing agent, Neurodazine allows neurogenic conversion of both differentiated immature myotubes and mature skeletal muscle. Neurodazine is a potential alternative approach to using stem cells.
storage
Store at +4°C
References
1) Williams?et al. (2007),?Synthetic small molecules that induce neurogenesis in skeletal muscle; J. Am. Chem. Soc.,?129?9258